Name: William Denby

Theme: Coagulation

OPTION LIST

A	Megakaryocyte	I	Christmas Disease
B	Thromboxane A2	J	Factor VIII deficiency
C	Prostacyclin PGI2	K	Factor XII deficiency
D	Ehlers-Danlos Syndrome	L	Sensitised Platelet
E	Marfan Syndrome	M	Haemophilia
F	Autoimmune Thrombocytopenic Purpura	N
G	Vitamin K deficiency	O
H	von Willebrand Factor deficiency	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. This product of the Cyclic Endoperoxides induces platelet aggregation

2. A 6 foot 7 inch rower presents to his General Practitioner complaining of

easy skin bruising. On further examination he is found to have Pectus

Excavatum, lax joints and a high-arched palate.

3. A 62 year old overweight woman presents to the Emergency Department

following a Road Traffic Accident. A full set of investigations is carried out –

which shows an increased Activated Partial Thromboplastin Time (APTT) and

Prothrombin Time (PT)

4. A 25 year old man presents to the Emergency Department a day after

attending his dentist for a routine check-up. After treatment at the dentists the

previous day, his gums had not stopped bleeding. On investigation, his APTT

is prolonged but a normal PT.

5. A 16 year old girl presents to the Haematology Outpatients clinic describing a fluctuating history of easy bruising, epistaxis and menorrhagia. On investigation there is a thrombocytopaenia with increased megakaryocytes on BM examination.

ANSWERS

1. B

2. E

3. G

4. H

5. F